L-Glutathione Reduced

L-Glutathione Reduced
Details:
L-Glutathione Reduced (GSH) is a naturally occurring tripeptide made of three amino acids: cysteine, glutamic acid, and glycine. In skincare and cosmetic formulations, it's used as a key active ingredient in spot-lightening and skin-brightening products.
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Description
Technical Parameters

Overview

 

L-Glutathione Reduced (GSH) is a naturally occurring tripeptide made of three amino acids: cysteine, glutamic acid, and glycine. In skincare and cosmetic formulations, it's used as a key active ingredient in spot-lightening and skin-brightening products.

 

Product Specification

 

Item

Specification

CAS Number

70-18-8

Molecular Formula / Molecular Weight

C₁₀H₁₇N₃O₆S / 307.33 g/mol

Appearance

White to off-white crystalline powder, free of visible foreign particles

Assay (Purity)

98.0%–101.0% (dry basis), HPLC-verified per batch

Particle Size

80–120 mesh standard; 200 mesh micronized available upon request for improved dissolution rate

Solubility

≥200 mg/mL in water at 20°C; fully soluble in PBS (pH 7.2)

Heavy Metals

Lead ≤2 ppm; Arsenic ≤1 ppm; Mercury ≤0.1 ppm (tested per USP <231> method)

Loss on Drying

≤0.5%

Shelf Life

24 months from production date when sealed, stored below 25°C and protected from light

 

Key Features

 

Rapid Dissolution Rate
• Fully dissolves in water (20°C–25°C) within 90 seconds under standard industrial stirring (200–300 rpm), eliminating the need for heated mixing tanks.

• Formulation Compatibility: Demonstrates verified chemical stability when combined with Sodium Ascorbyl Phosphate and Niacinamide within a pH range of 5.5–7.0, showing zero crystallization, active ingredient precipitation, or pH drift during stability testing.

 

100–120 Mesh Particle Distribution
Uniform fine powder specification eliminates physical agglomeration and clumping during dry-blending, ensuring consistent batch homogeneity in commercial powder mixers without secondary milling.

 

Low-Odor Specification
Advanced chromatographic purification minimizes volatile sulfur impurities, suppressing characteristic mercaptan odors to expand formulation options in unscented, fragrance-free, or clean-beauty end products.

 

Thermal & Oxidation Stability
Controlled-temperature design limits conversion to oxidized glutathione (GSSG) to less than 2.0% over 12 months under sealed, non-refrigerated storage and transit conditions (≤25°C).

 

Applications & Formulation Guidelines

 

Topical Serums & Creams: Recommended inclusion rate of 0.5%–2.0% in leave-on skin brightening, spot-correcting, and evening skin-tone formulations.

 

PH Processing Window: Optimal bio-activity and molecular stability are strictly maintained between pH 5.0 and 7.5; processing outside this threshold accelerates ambient oxidation into inactive GSSG.

 

Synergistic Pairing: Fully compatible with multi-active tyrosinase-inhibition systems containing Alpha Arbutin, Tranexamic Acid, or Azelaic Acid with zero color degradation or batch yellowing.

 

Application Grade Restriction: This material is strictly certified for Cosmetic and Oral Nutricosmetic applications; it is non-sterile and strictly prohibited for intravenous (IV) or injectable pharmaceutical formulations.

 

Stability & Oxidation Performance

 

GSSG Conversion Threshold: Guaranteed assay purity of ≥98.0% with oxidized glutathione (GSSG) limited below 1.5%, ensuring consistent appearance and skin-lightening efficacy in finished cosmetic batches to eliminate downstream consumer complaints.

 

Accelerated Stability (40°C / 75% RH): Retains greater than 95% active thiol groups after 6 months of stress testing in nitrogen-flushed aluminum packaging, supporting a documented 24-month commercial shelf-life under standard warehouse storage.

 

Formulation Matrix Compatibility: Stable within a pH range of 3.5–5.5; effectively prevents localized matrix yellowing and inhibits thiol-odor degradation in water-based serums, eliminating the need for costly masking agents or high fragrance dosages.

 

Photostability & Handling Protocols: Remains stable during cleanroom ambient daylight processing windows; shipped in light-proof, double-layer anti-static PE bags inside fiber drums to prevent moisture absorption and caking during bulk unpalletization, ensuring precise automated weighing and zero production waste.

 

Packaging & Logistics

 

Order & Sample: Complimentary 50g–100g samples available for verified B2B R&D evaluations (limit one per enterprise per year) dispatched within 3 business days; commercial trial MOQ starts at 25 kg; standard commercial contract runs begin at 1 metric ton.

 

Standard Packaging: Double-layer vacuum-sealed aluminum foil bags inside heavy-duty fiber drums, standardized at 25 kg net weight per drum to interface seamlessly with gravity-fed batch charging systems.

 

Custom Sub-Packaging: Private labeling and customized packaging divisions (e.g., 1 kg or 5 kg packs) are available for contract volumes exceeding 500 kg.

 

Lead Times: 7–10 business days for ex-stock warehouse fulfillment; 25–30 days for custom manufacturing runs exceeding 5 MT.

 

Commercial Shipping Terms: Standard delivery via FOB Shanghai or FOB Ningbo; EXW, CIF, and full DDP options are negotiable upon RFQ submission.

 

Compliance

 

Regulatory Status: REACH-registered for EU market access; US MoCRA FDA Facility Registration and Cosmetic Ingredient Listing completed; meets all US FDA dietary supplement requirements.

 

Quality Documentation: Every commercial lot is accompanied by an ICP-MS tested Certificate of Analysis (COA) guaranteeing assay purity ≥ 98.0%, controlled heavy metal thresholds, and negative microbial counts at no additional cost.

 

Facility Certifications: Synthesized via clean fermentation in a third-party audited facility certified under ISO 9001:2015 and ISO 22716 (Cosmetic GMP standards).

 

Batch Traceability: Every 25 kg drum features an individual barcode linkage, enabling immediate digital recall tracking back to the specific fermentation log, raw material input lots, and QC sign-off records.

 

FAQ

 

Q: Can you support private label or custom packaging?

A: Yes. Private labeling, custom carton design, and sub-packaging options are available for OEM and contract manufacturing customers with volumes above 500 kg.

Q: What is the recommended manufacturing temperature during blending?

A: Recommended processing temperature is below 40°C. Higher temperatures increase oxidation risk and may reduce active content over time.

Q: Does the ingredient change color during storage?

A: When properly sealed and protected from light and oxygen, the product remains white to off-white. Slight yellowing may occur if exposed to air or elevated humidity over extended periods.

Q: Does particle size affect performance in formulation?

A: Yes. Finer particle grades (e.g., 200 mesh micronized) improve dissolution speed and reduce mixing time, especially in cold-process manufacturing systems.

Q: What payment terms do you support for international orders?

A: We support multiple international payment methods including T/T (bank transfer), L/C at sight for bulk contracts, and negotiated NET terms for long-term OEM partners after credit evaluation.

 

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