Overview
Acetyl Glutathione is a stabilized derivative of glutathione designed for cosmetic and dermatological formulations focused on skin tone correction.
Product Specification
|
Category |
Specification |
|
INCI Name |
Acetyl Glutathione (S-Acetyl-L-Glutathione) |
|
CAS Number |
34396-04-8 |
|
Molecular Formula |
C₁₂H₁₉N₃O₇S |
|
Molecular Weight |
349.36 g/mol |
|
Appearance |
White to off-white crystalline powder |
|
Assay (Purity) |
≥98.0% (HPLC) |
|
Solubility |
Freely soluble in water (≥50 g/L at 25°C); slightly soluble in ethanol |
|
pH (1% aqueous solution) |
4.0 – 6.0 |
|
Loss on Drying |
≤5.0% |
|
Particle Size |
95% pass through 80 mesh |
|
Storage Conditions |
Store sealed, below 25°C, protected from light and moisture |
|
Shelf Life / Stability |
24 months under recommended storage conditions |
Key Feature
PH Stability: Stable operating window within pH 4.0–7.0. Formula buffering is required before active introduction to prevent acid/base hydrolysis.
Thermal Tolerance: Add during the cool-down phase below 40°C for aqueous systems. Formulations can tolerate transient exposure up to 60°C during high-speed shear mixing without assay degradation.
Solubility: Directly water-soluble before emulsification, eliminating the need for organic solvents, glycol pre-dispersion, or carrier oils.
Synergistic Compatibility: Documented stability in multi-active whitening systems containing Ascorbic Acid, Niacinamide, Alpha-Arbutin, Tranexamic Acid, and Hyaluronic Acid.
Formulation Restrictions: Incompatible with high-concentration AHA/BHA systems operating below pH 3.5 due to acid-catalyzed cleavage of the protective acetyl group.
Quality Control
Facility & Cross-Contamination Control: Manufactured under ISO 9001:2015 standards with dedicated, validated separate production lines for cosmetic-grade actives to eliminate cross-contamination risks.
Regulatory Registrations: Fully REACH registered for unrestricted European Union import, compliance, and distribution.
Batch Analytics: Dual-verification QA protocol requiring full in-house elemental impurities (ICP-MS), microbial screening, and HPLC assay purity testing before every batch release.
Traceability: Full forward and backward lot traceability from raw material chemical precursor batches to finished commercial drums within 24 hours.
Audit Transparency: Annual third-party facility audit reports, Safety Data Sheets (SDS), and compliance data packages are shared openly upon standard corporate NDA.
Supply Capacity
Synthesis Methodology: Manufactured via directed enzymatic synthesis, eliminating the structural isomers and high batch-to-batch color/odor variance common in traditional fermentation alternatives.
Capacity Scaling: Current production capacity stands at 8 metric tons/month, scalable to 15 metric tons/month within 60 days of contractual forecast adjustments.
Supply Continuity Strategy: Continuous rolling safety stock of 2 metric tons maintained at all times to insulate contracted buyers from lead-time gaps.
Custom Grades: Tailored purity profiles (99%+) and customized micronization options available for advanced applications with a 100kg minimum campaign run.
Commercial Terms
Standard Industrial Packaging: 1kg airtight aluminum foil bags (inner) packed within 25kg heavy-duty fiber drums (outer), factory nitrogen-flushed as standard to prevent oxidation and moisture absorption.
Commercial MOQ: 25kg (one standard drum) minimum for commercial orders; tiered contract pricing applies to orders exceeding 100kg.
Lead Times: 10–15 business days for ex-stock warehouse inventory; 30–35 days for custom particle sizing or private-label custom packaging runs.
Storage Matrix: Maintain sealed containers below 25°C, away from direct UV exposure and localized heat sources. Standardized handling guides are appended to all pallets.
R&D Sample Protocol: 50g–100g verification samples dispatched within 3 business days accompanied by batch-specific COAs and a Tech-Pack containing 3 validated starter formulas (Serum, Cream, Mask).
FAQ
Q: How is long-term price stability handled in contract supply?
A: Pricing is generally linked to raw precursor cost fluctuations and annual forecast volume commitments. Long-term buyers often negotiate fixed pricing bands with quarterly review clauses rather than fully fixed pricing.
Q: What are the accepted payment methods for international orders?
A: We typically accept T/T (bank transfer) as the standard method. For qualified long-term clients, L/C at sight or split payment terms (deposit + balance before shipment) can be arranged depending on order volume and credit assessment.
Q: If regulatory frameworks change (EU REACH update or China NMPA revision), who is responsible for compliance updates?
A: In standard B2B supply agreements, the manufacturer is responsible for maintaining updated compliance documentation, but the brand owner remains responsible for final product registration in each market.
Q: Can this ingredient be dual-sourced, or is it typically single-source dependent?
A: Although multiple manufacturers exist globally, buyers should avoid single-batch qualification without secondary supplier validation due to supply chain concentration risk in specialty acetylated actives.
Q: What regulatory documentation is typically required for EU and US market clearance?
A: Most procurement teams require REACH confirmation (EU), SDS aligned with GHS classification, and impurity heavy metal declaration. For US cosmetic use, buyers typically also request IFRA-related compatibility statements if fragrance systems are involved.
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